• Introduction DHFR is an important enzyme in both mammals and

  2019-08-05

  

  Introduction DHFR is an important enzyme in both mammals and microorganism including Mycobacterium tuberculosis (Mtb). It catalyzes folic mek inhibitors conversion to dihydro and tetrahydro folic acid which is a crucial step in folate pathway [1]. Inhibition of folate pathway leads to interruption

• Introduction Collagen deposition is a common feature found

  2019-08-05

  

  Introduction Collagen deposition is a common feature found in cancerous tissues and fibrotic organs/lesions. It is now well accepted that collagen deposition is not just a consequence of disease, but that it can also trigger a vicious cycle. Both chemical and physical signals elicited from collagen

• The crystal structure of the

  2019-08-05

  

  The crystal structure of the B. subtilis Maf (BSU28050) was published in 2000, and, to date, it represents the only experimental work with a purified Maf protein (Minasov et al., 2000). The structure revealed a structural fold similar to that found in ITPases and YjjX proteins, which are nucleotide

• br Cyclin dependent kinases control more than cell

  2019-08-05

  

  Cyclin-dependent kinases control more than cell cycle CDKs’ roles conducting the concert of 5-Methyl-UTP was first revealed in the context of the tumor suppressor Rb, phosphorylation of which by CDK4 or CDK6 inactivates it loosing the transcription factor E2F [1], [12], [15]. Discovery of other

• CPTH2 hydrochloride br The modulation of ER

  2019-08-02

  

  The modulation of ERα: from SERMs to TSECs Continued efforts to provide women with efficacious menopausal therapies have generated interest in the development of selective CPTH2 hydrochloride receptor modulators (SERMs). Similar to estrogens, SERMs have been shown to bind to ERs with high affinit

• br The modulation of ER

  2019-08-02

  

  The modulation of ERα: from SERMs to TSECs Continued efforts to provide women with efficacious menopausal therapies have generated interest in the development of selective Cordycepin receptor modulators (SERMs). Similar to estrogens, SERMs have been shown to bind to ERs with high affinity, despit

• Two GPCR subtypes of interest in the myocardium

  2019-08-02

  

  Two GPCR subtypes of interest in the myocardium are the endothelin receptor (ETR) and the α1-adrenergic receptor (α1-AR). Upon ligand binding, these receptors canonically activate the Gαq protein leading to activation of phospholipase C, hydrolysis of phosphatidylinositol 4,5-bisphosphate into diacy

• A recent study reports the expression of glutathione depende

  2019-08-02

  

  A recent study reports the expression of glutathione-dependent enzymes (GGT, GST-isoforms, gamma-glutamylcysteine synthetase, glutathione disulfide reductase and GSH peroxidase) in human primary PT NG,NG-dimethyl-L-Arginine hydrochloride in four subsequent passages [33]. In this study, we present ph

• We propose the following model for

  2019-08-02

  

  We propose the following model for how B cell-guiding EBI2 ligand gradients are established in lymphoid tissues. CH25H and CYP7B1 are needed in radiation-resistant stromal cells, are abundantly expressed and active in CXCL13+ and CCL21+ FRCs, but not lymphocytes, and are poorly expressed in the inne

• br DAG kinase activity is confined to specific cell

  2019-08-02

  

  DAG kinase activity is confined to specific cell compartments A number of reports demonstrating agonist-dependent translocation of DGKs to distinct membrane compartments suggest that DGK activity is restricted to localized DAG pools generated after activation of receptors. Perhaps the best eviden

• RDH belongs to C family of the short

  2019-08-02

  

  RDH10 belongs to 16C family of the short-chain dehydrogenase/reductase (SDRs) superfamily of proteins [12], [13]. Notably, in human genome adjacent to the gene encoding RDH10 on chromosome 8 are located two other genes encoding members of the SDR16C family: retinol dehydrogenase epidermal 2 (RDHE2,

• ApoE is secreted from astrocytes glia

  2019-08-01

  

  ApoE is secreted from astrocytes/glia into the interstitial fluid and is important for metabolizing Aβ because of its propensity for binding Aβ as a cholesterol and phospholipid acceptor in reverse cholesterol transport [8]. Aβ oligomers show a direct toxicity to neurons, and ApoE inhibits oligomer

• The hepatic constitutive levels of CYP

  2019-08-01

  

  The hepatic constitutive levels of CYP1A2 were minimal and were below detectable limits in the kidney, indicating an organ-specific trend which has been reported by other groups (Hawke and Welch, 1985, Paolini et al., 1997, Parkinson, 1996, Villard et al., 1998). Retinol administration did not have

• br Competing interests br Acknowledgements br Introduction D

  2019-08-01

  

  Competing interests Acknowledgements Introduction Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) in biomembranes to produce phosphatidic Dihydrotestosterone solubility (PA) [1], [2], [3], [4], [5], [6]. To date, ten mammalian DGK isozymes (α, β, γ, δ, ε, ζ, η, θ, ι and κ) h

• There have been two reports

  2019-08-01

  

  There have been two reports of tumor shrinkage in response to dasatinib treatment in lung SCC patients harboring the DDR2 kinase domain S768R mutation., In the first case described by Hammerman et al. a combination of erlotinib (an epithelial growth factor receptor inhibitor) and dasatinib was admin

16386 records 1011/1093 page Previous Next First page 上5页 10111012101310141015 下5页 Last page