• RA plays an instrumental role

  2018-11-12

  

  RA plays an instrumental role in neuronal differentiation and neuronal patterning as well as motor axon generation. In addition, RA is required for the maintenance of mature adult neurons (reviewed in Ferri et al., 2007). Various concentrations of RA (from 1 to 10μM) have been used to induce ESCs in

• br Materials and methods br Results

  2018-11-12

  

  Materials and methods Results Discussion Heat shock, one of environmental factors, induces HSFs, leading to induction of HSPs involved in stress responses. In human and mouse ESCs, HSPs have been reported to be associated with self-renewal of ESCs by mediating folding and nuclear delivery o

• br Materials and methods br Results There are a number

  2018-11-12

  

  Materials and methods Results There are a number of complex methods for the generation of neural subtypes from hESCs and iPSCs. In most of them, intact pluripotent colonies are first lifted, induced to form EBs, and then grown in the presence of lineage specific morphogens and growth factors t

• The following are the supplementary data

  2018-11-12

  

  The following are the supplementary data related to this article. Acknowledgments This study was supported by the Korea Healthcare Technology R&D Project, Ministry of Health, Welfare, and Family Affairs, Republic of Korea (Grant no. A120262) and a 2012 grant (10172KFDA993) from the Korea Food &

• br Results br Discussion The range of cell types in

  2018-11-09

  

  Results Discussion The range of cell types in Haemopedia makes identification of lineage-specific genes more rigorous. The genes that we have identified as lineage signatures are highly specific to each lineage and are lineage specific in other datasets (Figure S5). This provides a powerful re

• Our screening strategy permitted identification of two allel

  2018-11-09

  

  Our screening strategy permitted identification of two leukotriene receptor agonist of Rbf, a core cell-cycle regulator required for metamorphosis and survival, which would be precluded from sterility-based screens. The overproliferating germ cells present in the Rbf null allele did not divide synch

• To study the cellular and molecular events of

  2018-11-09

  

  To study the cellular and molecular events of FTD3, we derived a disease model using human iPSCs from patients carrying the 31449G > C mutation in CHMP2B and isogenic controls generated via the CRISPR/Cas9 system with subsequent in vitro neuronal differentiation. Our model not only confirmed partly

• Pluripotent ESCs and induced pluripotent stem

  2018-11-09

  

  Pluripotent ESCs and induced pluripotent stem e1 activating enzyme (iPSCs) represent a potentially unlimited source of skeletal cells for therapeutic applications. Several studies have established defined culture conditions to direct differentiation of mouse/human ESCs and human iPSCs into chondrog

• br Results and discussion br The main

  2018-11-09

  

  Results and discussion The main experimental results are as follows: The existence of internal electrical and mechanical fields is one of the reasons for phase transition diffusion [14], leading to the disruption of the polarization direction invariance and requiring to take into account the

• We also revealed that Scd is a

  2018-11-09

  

  We also revealed that Scd1 is a functional target of miR-378 that promotes lipolysis in adipose tissues of miR-378 Tg mice. SCD1 critically regulates lipid metabolism, and dysregulation of SCD1 activity results in various metabolic disorders, including diabetes, cardiovascular disease, and obesity (

• Cause specific mortality and morbidity outcomes in the

  2018-11-09

  

  Cause-specific mortality and morbidity outcomes in the systematic review and meta-analysis are reported using the International Classification of Disease (ICD 10) nomenclature and hierarchy (Supplementary File S5). A total of 13 publications were suitable for only the systematic review, including st

• miR mimics are also currently under Phase I clinical

  2018-11-09

  

  miR-16 mimics are also currently under Phase I clinical trials for patients with Malignant Pleural Mesothelioma (MPM) and Advanced Non-Small Cell Lung Cancer (NSCLC) that have failed standard therapy. These miR-16 mimics were delivered intravenously, using EnGeneIC Delivery Vehicle (EDV)-Packaging,

• Although more GWAS on sepsis

  2018-11-09

  

  Although more GWAS on sepsis traits will be accomplished in the coming years, it is worth noting that these studies allow analyzing a modest fraction of all existing variants in our genome. In , present their results from a study using a promising alternative taking advantage of high-throughput DNA

• Notably the sleeping environment in

  2018-11-09

  

  Notably, the sleeping environment in which home studies are conducted is often not standardized especially with respect to ambient temperatures due to seasonal changes. According to the data collected from Summer 2012 to Summer 2014 in Australian houses by the Faculty of Architecture, The University

• Among sleep disorders obstructive sleep apnea syndrome SAOS

  2018-11-09

  

  Among sleep disorders, obstructive sleep estrogen related receptor syndrome (SAOS) is very common among the older adult [14,15]. SAOS occurs when there is a repeated obstruction of the upper airway during sleep for 10s or more, accompanied by oxyhemoglobin desaturation, causing micro-arousals and aw

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