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br Conclusions Complicated and changeable environment and
2018-10-31
Conclusions Complicated and changeable environment, and the external stress can perturb mitochondrial function, cells evolve multiple signaling pathways to adapt to protect mitochondria and maintain cellular homeostasis. The molecular mechanisms of mitochondrial stress signaling pathways are quit
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THz Biomed or THz radiation
2018-10-31
THz-Biomed, or THz radiation, is proposed an efficient, label-free, reagent-less and nondestructive detection methods, which is indispensable for laboratory medicine. Studies show that low-frequency internal motions (e.g., skeleton vibration and rotation) and weak bonds (e.g., Hydrogen bond and van
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At the time not all scholars appreciated these innovations T
2018-10-31
At the time, not all scholars appreciated these innovations. The compatibility of the support with the displayed object and the relevance of the showcases within the architectural container were related to a modern functionalist approach that was hard to understand for those who were not accustomed
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Rationale Anterior cervical discectomy and fusion ACDF has b
2018-10-31
Rationale Anterior cervical discectomy and fusion (ACDF) has been accepted as the gold standard of surgical management for cervical spondylosis and disc disease causing radiculopathy or myelopathy. High patient-satisfaction scores and high arthrodesis rates associated with ACDF have been reported
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br Conclusions The results of this study are
2018-10-31
Conclusions The results of this study are significant for a deeper understanding of the cellular changes that take place during ex vivo expansion of BMSCs and ASCs, and appear to concur with current knowledge on the use of hypoxic environments and the occurrence of replicative senescence. Relevan
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BMSCs interfere with DC differentiation maturation and
2018-10-31
BMSCs interfere with DC differentiation, maturation and function. IL-6 was initially thought as the main effector in the inhibition of DC differentiation by BMSCs. Djouda et al. reported that murine MSCs secreted high level of IL-6, which down-regulates the expression of MHC II, CD40, and CD86 on ma
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The ubiquitin proteasome degradation mechanism is
2018-10-31
The ubiquitin–proteasome degradation mechanism is associated with most intracellular proteins, including membrane-surface receptors (Gesbert et al., 2005; Martinez-Moczygemba et al., 2007; Rocca et al., 2001; Wauman et al., 2011). Over 60 Fbox proteins have been identified, but only a few, such as β
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Intestinal stem cells have been identified
2018-10-31
Intestinal stem cells have been identified by various markers, such as musashi-1 (Msi1), hairy enhancer of split-1 (Hes1), CD133, leucine-rich repeats and immunoglobulin-like domains protein 1 (Lrig1) (Kayahara et al., 2003; Potten et al., 2003; O\'Brien et al., 2007; Wong et al., 2012). More recent
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br Materials and methods br Results
2018-10-31
Materials and methods Results Discussion This present study and previous works in the literature have shown that mechanical stimulation promotes the proliferation of BMSCs (Luu et al., 2009). In this study, the presented results revealed that pressure promoted BMSC proliferation by facilita
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We exploited the fact that the eHBs were
2018-10-31
We exploited the fact that the eHBs were trapped as progenitors to analyze the effect of specific growth factors upon them and uncovered a central role for FGF (Figure 6). These data are consistent with studies in which FGF promoted the expansion of BL-CFCs derived from human or murine ESCs (Faloon
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br Acknowledgements This work was supported
2018-10-31
Acknowledgements This work was supported by the IRET Foundation (2015-2016), Ozzano Emilia, Italy (no-profit organization), in the frame of the “Step-by-step” POR-FESR 2016-2020 Emilia Romagna Region project. Introduction Resident neural stem cells (NSCs) persist in the adult mammalian centr
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We further show that Zfp iNSCs lines established from fetal
2018-10-31
We further show that Zfp521-iNSCs lines established from fetal, neonatal, and adult fibroblasts have the capacity to differentiate in vitro into the three main cell types: neurons, astrocytes and oligodendrocytes. This trilineage differentiation potential was also retained in three clonally derived
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Myofibrils are the smallest subunit of the cardiomyocyte
2018-10-31
Myofibrils are the smallest subunit of the cardiomyocyte contractile apparatus and consist of sarcomeres (single contractile units) in series. Here we present a method to measure the mechanical properties of single myofibrils isolated from hiPSC-CMs by a fast solution switching method (Colomo et al.
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We carry out age decomposition using Andreev s stepwise deco
2018-10-30
We carry out age decomposition using Andreev\'s stepwise decomposition algorithm within the Microsoft Excel Spreadsheets developed by Shkolnikov and Andreev (2010). Decomposition methods have been widely applied in research to partition the absolute difference in life expectancy or lifespan variatio
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Our research has identified that
2018-10-30
Our research has identified that behavioural indicators are the least important of the categories determining the inequality gap in mental health and wellbeing. This is true for both mental health measures. This is important, as much public health activity focused on reducing health inequalities ten
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