In conclusion the Olfm IRES eGFPCreERT allele described here

2018-10-20

In conclusion, the Olfm4-IRES-eGFPCreERT2 allele described here provides a tool, separate from Lgr5, that can be used to further characterize intestinal stem cells. Experimental Procedures Acknowledgments We thank Hugo Snippert for analysis of the Olfm4 animals and Valentina Sasselli for a cr

The meniscus is best described as

2018-10-20

The meniscus is best described as a fibrocartilage (Benjamin and Evans, 1990) comprising an outer, “red vascularized” part and an inner “white, unvascularized” part harboring round fibrochondrocytes (Hellio Le Graverand et al., 2001). Additionally, the outer surface of the meniscus is enclosed by a

br Results br Discussion hESCs demonstrate the potential to

2018-10-20

Results Discussion hESCs demonstrate the potential to serve as a starting cell population for bone regeneration, and previous studies report effective differentiation of hESCs to osteogenic lineage (Arpornmaeklong et al., 2010; Kärner et al., 2009). However, it remains important to better defi

Articular cartilage is highly lubricious Lubricin encoded by

2018-10-20

Articular cartilage is highly lubricious. Lubricin encoded by the PRG4 gene and glycosaminoglycans contribute to maintaining the low friction of cartilage and directly inhibit cell adhesion (Englert et al., 2005). Therefore, since the hiPSC-derived particles expressed PRG4, it is reasonable that the

Transplantation of cadaveric human islets can

2018-10-20

Transplantation of cadaveric human islets can restore insulin-independence in patients with type 1 diabetes (Shapiro et al., 2000; Ryan et al., 2001), but this approach has not been actively pursued for type 2 diabetes, likely due to the inadequate supply of donor islets, risk of immunosuppression,

The Xenopus homolog of Bucky ball is

2018-10-20

The Xenopus homolog of Bucky ball is known as XVelo (Vegetally localized −1), first identified based on the vegetal pole localization of XVelo RNA (Claussen and Pieler, 2004). A recent study identified XVelo as a Balbiani body enriched protein, and identified prion-like sequences within the amino te

In the present study we present a

2018-10-20

In the present study, we present a step-by-step strategy by which gene-corrected osteopetrotic iPSCs were used to generate hematopoietic progenitor SAG supplier able to give rise in vitro to functional osteoclasts, thus providing a proof of principle for an autologous cell therapy approach to treat

We previously discovered that ATM

2018-10-20

We previously discovered that ATM, in addition to serving many roles in cell-cycle regulation and DNA damage response, also functions as a key epigenetic regulator in neurons, likely underlying the ataxic symptoms as well as neurodegeneration. ATM indirectly regulates nuclear-cytoplasmic shuttling o

The AGM explant culture is

2018-10-20

The AGM explant culture is known to increase HSC activity. Whether the increase in AGM explant HSCs is due to the expansion and shift in BMP-activation status of existing HSCs, or the new generation of HSCs (non-BMP-activated), or both, remains unclear. Secondary transplantations of GFP+ and GFP− BM

br Results br Discussion The adult kidney has a low

2018-10-20

Results Discussion The adult kidney has a low rate of homeostatic cell cycling; yet, following injury, even one severe enough to cause total renal failure, widespread cell proliferation and functional recovery can occur. The mechanisms responsible for generation of new kidney cesium chloride

br Introduction Cardiac morphogenesis results

2018-10-20

Introduction Cardiac morphogenesis results from the specification, differentiation, and migration of spatially and temporally distinct sets of cardiac precursor RGDfK that give rise to the mature cardiac tissue. The first multipotent cardiogenic cells originate from the mesoderm formed at early

Male hypogonadism is characterized by the low production of

2018-10-20

Male hypogonadism is characterized by the low production of testosterone, which is associated with typical symptoms including mood disturbance, sexual dysfunction, decreased muscle mass and strength, and decreased bone mineral density (Howell et al., 2000). Hypogonadism affects approximately 30% of

Hello world!

2018-07-29