• Rationale Anterior cervical discectomy and fusion ACDF has b

  2018-10-31

  

  Rationale Anterior cervical discectomy and fusion (ACDF) has been accepted as the gold standard of surgical management for cervical spondylosis and disc disease causing radiculopathy or myelopathy. High patient-satisfaction scores and high arthrodesis rates associated with ACDF have been reported

• br Conclusions The results of this study are

  2018-10-31

  

  Conclusions The results of this study are significant for a deeper understanding of the cellular changes that take place during ex vivo expansion of BMSCs and ASCs, and appear to concur with current knowledge on the use of hypoxic environments and the occurrence of replicative senescence. Relevan

• BMSCs interfere with DC differentiation maturation and

  2018-10-31

  

  BMSCs interfere with DC differentiation, maturation and function. IL-6 was initially thought as the main effector in the inhibition of DC differentiation by BMSCs. Djouda et al. reported that murine MSCs secreted high level of IL-6, which down-regulates the expression of MHC II, CD40, and CD86 on ma

• The ubiquitin proteasome degradation mechanism is

  2018-10-31

  

  The ubiquitin–proteasome degradation mechanism is associated with most intracellular proteins, including membrane-surface receptors (Gesbert et al., 2005; Martinez-Moczygemba et al., 2007; Rocca et al., 2001; Wauman et al., 2011). Over 60 Fbox proteins have been identified, but only a few, such as β

• Intestinal stem cells have been identified

  2018-10-31

  

  Intestinal stem cells have been identified by various markers, such as musashi-1 (Msi1), hairy enhancer of split-1 (Hes1), CD133, leucine-rich repeats and immunoglobulin-like domains protein 1 (Lrig1) (Kayahara et al., 2003; Potten et al., 2003; O\'Brien et al., 2007; Wong et al., 2012). More recent

• br Materials and methods br Results

  2018-10-31

  

  Materials and methods Results Discussion This present study and previous works in the literature have shown that mechanical stimulation promotes the proliferation of BMSCs (Luu et al., 2009). In this study, the presented results revealed that pressure promoted BMSC proliferation by facilita

• We exploited the fact that the eHBs were

  2018-10-31

  

  We exploited the fact that the eHBs were trapped as progenitors to analyze the effect of specific growth factors upon them and uncovered a central role for FGF (Figure 6). These data are consistent with studies in which FGF promoted the expansion of BL-CFCs derived from human or murine ESCs (Faloon

• br Acknowledgements This work was supported

  2018-10-31

  

  Acknowledgements This work was supported by the IRET Foundation (2015-2016), Ozzano Emilia, Italy (no-profit organization), in the frame of the “Step-by-step” POR-FESR 2016-2020 Emilia Romagna Region project. Introduction Resident neural stem cells (NSCs) persist in the adult mammalian centr

• We further show that Zfp iNSCs lines established from fetal

  2018-10-31

  

  We further show that Zfp521-iNSCs lines established from fetal, neonatal, and adult fibroblasts have the capacity to differentiate in vitro into the three main cell types: neurons, astrocytes and oligodendrocytes. This trilineage differentiation potential was also retained in three clonally derived

• Myofibrils are the smallest subunit of the cardiomyocyte

  2018-10-31

  

  Myofibrils are the smallest subunit of the cardiomyocyte contractile apparatus and consist of sarcomeres (single contractile units) in series. Here we present a method to measure the mechanical properties of single myofibrils isolated from hiPSC-CMs by a fast solution switching method (Colomo et al.

• We carry out age decomposition using Andreev s stepwise deco

  2018-10-30

  

  We carry out age decomposition using Andreev\'s stepwise decomposition algorithm within the Microsoft Excel Spreadsheets developed by Shkolnikov and Andreev (2010). Decomposition methods have been widely applied in research to partition the absolute difference in life expectancy or lifespan variatio

• Our research has identified that

  2018-10-30

  

  Our research has identified that behavioural indicators are the least important of the categories determining the inequality gap in mental health and wellbeing. This is true for both mental health measures. This is important, as much public health activity focused on reducing health inequalities ten

• br Methods br Results br Discussion Our

  2018-10-30

  

  Methods Results Discussion Our study suggests that parp inhibitor lower educational attainment is associated with increased odds of multimorbidity in a U.S. population-based sample of adults ages 30–64. Specifically, individuals with less than a high school degree as well as those with a hi

• Community capacity building eschews a focus

  2018-10-30

  

  Community capacity building eschews a focus on deficits and considers concepts of place through residents’ sense of mineralocorticoid receptor (Jung & Viswanath, 2013), and perceived collective efficacy. Consistent with Ellaway et al.’s (2001) findings that perceived problems within a community wer

• Speed of performance work rates number of problems

  2018-10-30

  

  Speed of performance [75], work rates ([17,24,98][87]), number of problems attempted [4,13,41]; Webb and Levy, 1984) and choice of tasks of various degrees of difficulty [7,79] have been used to determine performance effort. The subjective experience of effort is the sense of perceived exertion when

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