• We have utilized an adenovirus Ad vector as a tool

  2018-11-08

  

  We have utilized an adenovirus (Ad) vector as a tool for transduction of functional genes into stem cells, because Ad vectors are relatively easy to construct, can be produced at high titers, and mediate efficient and transient gene expression in both dividing and nondividing cells. We have demonstr

• With the advent of factor based reprogramming induced

  2018-11-08

  

  With the advent of factor-based reprogramming, induced pluripotent stem cells can be readily obtained from patients with a variety of genetic diseases (Dimos et al., 2008; Park et al., 2008; Takahashi and Yamanaka, 2006), but several limitations exist to factor based reprogramming as models for dis

• br Material and methods br

  2018-11-08

  

  Material and methods Results Discussion The current study is the first report of the dynamic expression of ATF3 by ependymal spinal stem cells, as this protein was localized to the cytoplasm when such cells were quiescent, but was found in their nucleus when cells became activated. This pro

• br Materials and methods br Results br Discussion This

  2018-11-08

  

  Materials and methods Results Discussion This present study and previous works in the literature have shown that mechanical stimulation promotes the proliferation of BMSCs (Luu et al., 2009). In this study, the presented results revealed that pressure promoted BMSC proliferation by facilita

• After comparing the lymph angiogenic effects of HLE and HLF

  2018-11-08

  

  After comparing the (lymph)angiogenic effects of HLE and HLF, UVB-induced changes in their protein expression patterns were also assessed. As shown by the protein array assessment, following UVB irradiation of HLF Phos-tag Acrylamide amphiregulin, uPA (a strong promoter of angiogenesis (Oh et al.,

• Our in vitro and in vivo studies

  2018-11-08

  

  Our in vitro and in vivo studies show an increase in neurogenesis in the presence of CsA. Our findings are consistent with the idea that CsA is enhancing the survival of DG NPCs and these cells proliferate to give rise to newly born neurons. We cannot rule out the possibility that the DG contains a

• Metabolic therapy has become trendy in attenuating the side

  2018-11-08

  

  Metabolic therapy has become trendy in attenuating the side effects of glioma treatment (Schwartz et al., 2015; Zuccoli et al., 2010; Seyfried et al., 2015). This type of therapy is designed to disrupt tumor microenvironment, while enhancing the health and vitality of normal cells. It has been demon

• The primary determinant of the target specificity of an

  2018-11-08

  

  The primary determinant of the target specificity of an individual designer nuclease is the length of its DNA recognition site, which is different in ZFNs, TALENs and the CRISPR/Cas9 system. Also, the GC content substantially influences the target specificity. In theory, a 16bp recognition site shou

• br Conclusion Cellular reprogramming is an inefficient proce

  2018-11-08

  

  Conclusion Cellular reprogramming is an inefficient process and obtaining the rare reprogramming intermediates is a major hurdle in understanding this important event at the molecular level. The application of certain techniques that require higher cell numbers such as transcription factor ginger

• In our previous studies we successfully synthesized poly

  2018-11-08

  

  In our previous studies, we successfully synthesized poly(hydroxyethyl methacrylate) (pHEMA) derived-polymers differing in the amount of 2-methacryloyloxyethyltrimethyl ammonium chloride (METAC) (Rosso et al., 2003; De Rosa et al., 2004). We demonstrated that positively charged moieties on the polym

• The karyotype of the BIOT EHMT

  2018-11-08

  

  The karyotype of the BIOT-0708-EHMT1 iPSC line was determined with Giemsa-banding, proving normal diploid 46, XX karyotype, without any detectable abnormalities (Fig. 1B). In parallel, the pathogenic NM_024757.4(EHMT1):c.3413G>A mutation was confirmed by Sanger sequencing in the newly established iP

• Also critical to the success of

  2018-11-08

  

  Also critical to the success of hard tissue engineering strategies is the selection and use of an appropriate growth factor regimen. Although several growth factors are reported to play an important role in the process of matrix mineralisation, IGF-1 is the most abundant growth factor in bone matrix

• Using the combination of a mitogen activated protein

  2018-11-08

  

  Using the combination of a mitogen-activated protein kinase kinase (MEK) inhibitor, PD0325901 (PD03), and a glycogen synthase kinase 3 (GSK3) inhibitor, CHIR99021 (CHIR), which will hereafter be referred to as 2i, mouse ESCs (mESCs) are maintained in a ground state (Ying et al., 2008). CHIR activate

• neuron specific enolase Introduction Cell to cell competitio

  2018-11-08

  

  Introduction Cell-to-cell competition among male germline stem cells has been proposed to account for the higher frequency of some disorders among children of older fathers, a correlation referred to as the paternal age effect (PAE) (Goriely and Wilkie, 2012). In addition to compelling observations

• Proper functioning of the RPE is important for maintaining t

  2018-11-08

  

  Proper functioning of the RPE is important for maintaining the health and integrity of the outer retina, photoreceptors, and choriocapillaris. Healthy RPE cells play many crucial roles in the retina, including transportation of nutrients such as glucose or vitamin A from blood to the photoreceptors,

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