• The immunoregulatory and regenerative properties of MSCs mak

  2018-10-23

  

  The immunoregulatory and regenerative properties of MSCs make them ideal for use as therapeutic agents as they are uniquely positioned to suppress local inflammation and at the same time initiate tissue repair (). However, directing stem cell fate decisions towards a specific lineage is influenced

• In conclusion this first in human

  2018-10-23

  

  In conclusion, this first-in-human phase I study of VEDT was designed to establish the BED of VEDT for future investigations of the clinical activity of VEDT. VEDT is distinguished from other tocotrienols by its consistently superior anticancer activity in preclinical models. Although there are no a

• One major conserved DNA repair enzyme is the

  2018-10-23

  

  One major conserved DNA repair enzyme is the DNA2 helicase/nuclease (DNA2). Complete inactivation of either the helicase or nuclease activity of DNA2 in cells from a wide range of organisms, including yeast and humans, induces retinoic acid receptor arrest and cell death (Budd and Campbell, 1995; K

• Several conflicting large scale population based studies pub

  2018-10-23

  

  Several conflicting large-scale population-based studies published recently (e.g. (Lau et al., 2015; Moriya et al., 2015; Tsunoda et al., 2014)) indicated that p-gp inhibitors list moderate (or ‘non-alcoholic’) alcohol consumption either has a beneficial or detrimental association with prevalence o

• Hypothalamic hamartoma HH is a rare about

  2018-10-23

  

  Hypothalamic hamartoma (HH) is a rare (about 1:100,000) developmental, non-neoplastic malformation involving the small hypothalamic area located between the infundibular stalk and the mammillary bodies (). HH can be associated with a range of neurological and/or endocrinogical manifestations (). How

• Of note it is not known whether the

  2018-10-23

  

  Of note, it is not known whether the findings observed in the HOD model will translate to murine RBCs expressing other antigens, or to humans. Human studies investigating the role of RBC storage duration on alloimmunization and other adverse effects have reported varied outcomes (Dinardo et al., 201

• br Author contributions br Conflicts of Interest br Introduc

  2018-10-23

  

  Author contributions Conflicts of Interest Introduction With 15 million units transfused per year, red blood cell (RBC) transfusion is the most common procedure performed in United States hospitals (Pfuntner et al., 2013). Exposure to numerous foreign non-ABO RBC antigens during transfusion

• Despite its description over years ago by German

  2018-10-23

  

  Despite its description over 100years ago by German psychiatrist Alois Alzheimer, there has been little effective translation of insights on Alzheimer\'s disease (AD) pathobiology into effective treatments. As of 2015, roughly 50 million people globally — most over the age of 65years — have dementia

• The observational literature contains many investigations of

  2018-10-23

  

  The observational literature contains many investigations of racial differences in human TL, with findings that seem to contradict the association between shorter TL and stress. The majority of studies have found that U.S. blacks have longer telomeres than whites, despite on average lower socioecono

• It has previously been hypothesised that iron supplementatio

  2018-10-23

  

  It has previously been hypothesised that iron supplementation increases malaria susceptibility by increasing the availability of \'s preference for young RBCs (). observed significant shifts in RBC populations following iron supplementation, finding younger RBCs are most prevalent at Day 49 post iro

• To analyze whether loss of Sema f contributes to the

  2018-10-23

  

  To analyze whether loss of Sema3f contributes to the formation of subretinal neovascular lesions in Vldlr−/− mice, we designed two viral constructs using adeno-associated virus 2 (AAV2) vectors (Fig. 2A). The first construct (AAV2-GFP) was used for proof of principle experiments to test whether we c

• This study has several limitations First

  2018-10-23

  

  This study has several limitations. First, only papers published in English were included. Publications in languages other than English were excluded due to insufficient information, which may lead to selection bias. Second, this study involved largely Asians and Caucasians; other ethnic subgroups (

• So far RIO kinases have been

  2018-10-23

  

  So far, RIO kinases have been mostly studied in yeast, but the few studies addressing their function in mammalian cells identified an important role of all three family members in ribosomal biogenesis (Baumas et al., 2012; Ferreira-Cerca et al., 2014; Ferreira-Cerca et al., 2012; Turowski et al., 20

• The first SCAPs were identified through expression

  2018-10-23

  

  The first SCAPs were identified through expression profiling of senescent vs. non-senescent human ion channel and confirmed in RNA interference studies (Zhu et al., 2015b). The pathways included networks related to BCL-2/BCL-XL, PI3K/AKT, p53/p21/serpines, dependence receptors/tyrosine kinases, and

• A 779 manufacturer br Data Fasting during the light phase re

  2018-10-23

  

  Data Fasting during the light phase reduced oxygen consumption in female mice fed either a high-fat or standard diet (SD) for 3 days (Fig. 1B), but during the dark phase, fasting only reduced oxygen consumption when mice were fed a background high-fat diet (Fig. 1A). In both the dark and light ph

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