• The collagen field undoubtedly regains attractiveness with t

  2021-02-24

  

  The collagen field undoubtedly regains attractiveness with the emergence of new concepts (cell niche, regulation of growth factor bioavailability, mechanotransduction, cell microenvironment sensing) and new tools to investigate their in vivo functions (atomic force microscopy (AFM), second harmonic

• The mechanism underlying the increased

  2021-02-24

  

  The mechanism underlying the increased PON1 levels found in greenhouse workers may be accounted for by an increased protein Kaempferol-3-rutinoside receptor following pesticide interaction with different nuclear receptors as also occurs with other chemicals, such as polyphenols and statins [28]. A

• An ideal CHK inhibitor would be minimally cytotoxic while en

  2021-02-24

  

  An ideal CHK-1 inhibitor would be minimally cytotoxic, while enhancing the anti-tumor effect of a real cytotoxic agent that would be used in combination with the inhibitor. Our CHK-1 inhibitors have shown excellent selectivity over a panel of kinases including those regulating the cell cycle, but th

• When women reach the menopause they experience a number of

  2021-02-24

  

  When women reach the menopause they experience a number of physical complaints such as hot flushes, vaginal dryness and mood changes [1]. Bone loss also becomes manifest at this time [1], [2], but women will often not suffer from back pain before a vertebral fracture occurs. Women who have had one f

• Our present results support a major

  2021-02-24

  

  Our present results support a major role of EP1 receptors in peripheral heat sensitization and a smaller contribution to central heat sensitization but no contribution to mechanical sensitization. While the contribution of peripheral EP1 receptors to heat hyperalgesia is in good agreement with the a

• Key molecules in the EP second messenger signaling cascade t

  2021-02-24

  

  Key molecules in the EP1 second messenger signaling cascade that are necessary for potentiation of GluK2/GluK5 were identified. We also identified three GluK5 serines located in a membrane-proximal C-terminal domain that, when mutated to the phosphomimetic aspartate and expressed with GluK2, rendere

• Besides EGFR other tyrosine kinase receptors are currently

  2021-02-24

  

  Besides EGFR, other tyrosine kinase receptors are currently gaining attention as potential therapeutic targets. Included among these is the fibroblast growth factor receptor (FGFR) family, which is involved in the progression of a variety of cancers.7, 8, 9, 10, 11 In lung cancer, fibroblast growth

• With respect to bone metabolism and ossification related gen

  2021-02-24

  

  With respect to ‘bone metabolism and ossification’-related genes, treatment of SaOS-2 osteoblast-like PXD 101 with MS-10 up-regulated IGFBP-4, TG2, and SOST. Up-regulation of IGFBP-4 in SaOS-2 cells inhibits DNA and protein synthesis induced by IGF-1 (Kudo et al., 1995, Kudo et al., 1996). In addit

• roxadustat receptor br Results br Discussion Our UbV library

  2021-02-24

  

  Results Discussion Our UbV library was originally designed to develop inhibitors of deubiquitinases (Ernst et al., 2013). Recently, we showed that UbVs could exhibit multiple binding modes and mechanisms to modulate HECT E3 activity (Zhang et al., 2016)—one set occupied the HECT domain E2-bind

• br Acknowledgments This work was supported by

  2021-02-24

  

  Acknowledgments This work was supported by Grants from the National Research Foundation (2010-0000782) and the National Center for GM Crops (PJ008152) of the Next Generation BioGreen 21 Program funded by the Rural Development Administration, Republic of Korea, to W.T.K. Introduction Ubiquityl

• Currently two approaches can be used individually or

  2021-02-24

  

  Currently, two approaches can be used individually or combinedly to overcome weak immunogenicity of subunit PF-5274857 (Bookstaver et al., 2018; Moyle, 2017; Vartak and Sucheck, 2016). The first is to design particulate antigens. Virus-like particles (VLPs), for example—mainly derived from the capsi

• br Authors contributions br Acknowledgements br Introduction

  2021-02-23

  

  Authors’ contributions Acknowledgements Introduction Retinoic EPI-001 is a key signalling molecule in healthy development and in differentiation of stem cells, albeit uncontrolled levels of retinoic acid can lead to mutagenesis [1]. In eukaryotes retinoic acid is made by oxidation of all-t

• Collectively the results presented here provide new insights

  2021-02-23

  

  Collectively, the results presented here provide new insights into ligand binding, clustering, spatial distribution, and phosphorylation of DDR1b and DDR2 in response to soluble collagen I. As depicted in the cartoon of Scheme 1, we postulate a model in which the spatial distribution and assembly of

• For radiochemotherapy it is well known that mitotic

  2021-02-23

  

  For radiochemotherapy, it is well known that mitotic cell death and apoptosis present the major cell death modes. More recently, autophagy-dependent cell death has been described to occur upon radiochemotherapy (Daido et al., 2005, Song et al., 2017). This form of regulated cell death depends on com

• br Experimental methods br Results

  2021-02-23

  

  Experimental methods Results and discussion Conclusions Here we describe the first reported method for high-yield N1-Methylpseudouridine of active and soluble mature CPG2 (in the absence of the leader peptide) and its individual catalytic and dimerization domains in E. coli. Such a method i

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