• It is believed that emphysema in smokers

  2019-10-14

  

  It is believed that emphysema in smokers is mediated by proteases released from inflammatory EKI-785 pathway that cause destruction of the extracellular matrix in alveolar septa [1]. Metalloprotease-12 is mainly released by macrophages and is considered the enzyme responsible for emphysematous lesi

• br Introduction Detection of driver

  2019-10-14

  

  Introduction Detection of driver mutations in patients with advanced non-small cell lung cancer (NSCLC) is critical because they receive great benefit from kinase inhibitors [[1], [2], [3], [4]]. However, it is often difficult to obtain tumor tissue in advanced NSCLC patients. Cell-free DNA (cfDN

• Regorafenib and We have compared the potency

  2019-10-14

  

  We have compared the potency of a series of DNA-directed alkylating agents, including N-mustard-acridine, N-mustard-quinoline, and N-mustard-quinazoline conjugates previously synthesized in our laboratory [7], [13], and currently used drugs (oxaliplatin, cisplatin, or 5-FU) for the treatment of CRC

• br Protein acetylation Several reports show that MTX is

  2019-10-14

  

  Protein acetylation Several reports show that MTX is able to induce acetylation of histones and other proteins. Extensive studies have established that histone acetylation is primarily associated with gene activation. Acetylation occurs at lysine residues on the amino-terminal tail of the protein

• Based on the ability of CRF to modulate nociception

  2019-10-12

  

  Based on the ability of CRF to modulate nociception, we hypothesized that stress leads to hyperalgesia by the activation of CRF1 and/or CRF2 receptors in the spinal cord. We tested this hypothesis using an acute forced swim as a widely used and easily reproducible stressor and grip force as a measur

• Placental insufficiency is regarded as the main etiology for

  2019-10-12

  

  Placental insufficiency is regarded as the main etiology for FGR. Placental development is highly unique in eutherians and is regulated by numerous factors. For example, the novel retrotransposon-derived gene retrotransposon-like 1 (RTL1) was recently shown to play a key role in placental developmen

• Cancer has been linked to both genetic

  2019-10-12

  

  Cancer has been linked to both genetic and epigenetic changes. Epigenetic modifications, mainly DNA methylation at CpG dinucleotides, affect the regulation of gene transcription without altering the gene\'s sequence. Short sequences rich in CpG dinucleotides (i.e., CpG islands) are often found in th

• This article is based on previous research work

  2019-10-12

  

  This article is based on previous research work [43] in the field of distributed development of information systems [34]. In that work, the system infrastructure focusing on the three-level data model used in the different layers of our architecture is described. The work presented in this manuscrip

• br Introduction The dopaminergic system and its projections

  2019-10-12

  

  Introduction The dopaminergic system and its projections including both the prefrontal chemokine receptor (PFC) and striatum are known as being crucial to synaptic plasticity, skill acquisition and higher order functions (e.g., working memory and cognitive control; Matsumoto et al., 2003). Varia

• The P H activity and the large number of Hyp

  2019-10-12

  

  The P4H activity and the large number of 4-Hyp residues that are formed, amounting to half of all the Pro residues or 10% of all residues, have been identified as having a clear role in the structure and chemistry of the triple helix [3]. The role of the rare 3-Hyp residues is less clear and is stil

• The recombinant Scl collagen system has

  2019-10-12

  

  The recombinant Scl2 collagen system has shown capability as a biomaterial as well because of its adaptability and scalability. Scl2 was functionalized to crosslink into a hydrogel without disrupting its triple helix [130]. The Scl2–hydrogel crosslinking also did not disrupt cell adhesion and integr

• br Acknowledgements This work was supported by National Natu

  2019-10-12

  

  Acknowledgements This work was supported by National Natural Science Foundation of China (31701807, 31572000) and Jiangsu Province Science Foundation for Youths (BK20170491). Introduction Two Cl− channels of the ClC family, ClC-K1 and ClC-K2 (or their human orthologs ClC-Ka and ClC-Kb, respec

• Quercitrin In our former work our

  2019-10-12

  

  In our former work, our interest was in discovery of novel VEGFR-2 inhibitors as anti-angiogenesis agents. Along this line, with natural alkaloid taspine as the lead compound, rounds of structure optimization were performed to develop novel VEGFR-2 inhibitors [[13], [14], [15]]. Among them, BPS-7, b

• Several recent reviews have appeared covering different aspe

  2019-10-12

  

  Several recent reviews have appeared covering different aspects of the sPLA2 family of enzymes, including sPLA2-V, and the interested reader is kindly directed to these for specific details [34,[135], [136], [137]]. It is important to remark here, however, that recent studies on sPLA2-V suggest that

• DUBs are involved in cell cycle regulation and

  2019-10-12

  

  DUBs are involved in Salirasib regulation and DNA damage pathways and since, in cancer and different stress conditions all the proteins which regulate cell cycle and DNA damage/repair are either up/down regulated (Singh et al., 2013, Singh et al., 2011, Kumar and de Massy, 2010, Gupta et al., 2010)

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