• VER 155008: Advanced HSP70 Inhibition for Disease Modeling

  2025-09-28

  Explore VER 155008, a potent HSP 70 inhibitor, and its unique role in dissecting heat shock protein signaling and apoptosis in advanced disease models. This article offers a deeper, translational perspective on Hsp70 chaperone pathway inhibition and its impact on protein phase separation, setting it apart from existing literature.

• HyperScribe™ T7 Cy5 RNA Labeling Kit: Transforming RNA-Pr...

  2025-09-27

  Explore how the HyperScribe T7 High Yield Cy5 RNA Labeling Kit enables precise in vitro transcription RNA labeling for advanced RNA-protein interaction and phase separation research. Gain deep scientific insight into fluorescent nucleotide incorporation and probe design beyond conventional applications.

• RSL3 and the Ferroptosis Frontier: Redefining Cell Death ...

  2025-09-26

  Explore how RSL3, a potent glutathione peroxidase 4 inhibitor, is revolutionizing cancer biology by revealing ferroptosis as a distinct, targetable form of non-apoptotic cell death. This comprehensive analysis uncovers emerging intersections with transcriptional apoptosis and highlights advanced research applications.

• Clozapine N-oxide (CNO): Precision Chemogenetics for Anxi...

  2025-09-25

  Explore the advanced role of Clozapine N-oxide (CNO) in neuroscience as a selective chemogenetic actuator for dissecting anxiety-related circuits. This article uniquely bridges molecular pharmacology, circuit-level modulation, and translational insights, making it indispensable for GPCR signaling and schizophrenia research.

• ISRIB (trans-isomer): Redefining Integrated Stress Respon...

  2025-09-24

  Explore how ISRIB (trans-isomer) advances integrated stress response inhibition, offering unique mechanistic insights and translational applications for ER stress research, liver fibrosis, and cognitive enhancement. This article reveals new frontiers in ISRIB’s use beyond previous reviews, with emphasis on eIF2B activation and ATF4 targeting.

• Verapamil HCl: Novel Mechanisms in Osteoporosis and Infla...

  2025-09-23

  Explore how Verapamil HCl, a phenylalkylamine L-type calcium channel blocker, reveals new mechanistic insights in osteoporosis and arthritis inflammation models through TXNIP modulation and apoptosis induction.

• The only psychostimulant treatment option in Turkey is methy

  2025-03-03

  

  The only psychostimulant treatment option in Turkey is methylphenidate (Çetin et al., 2015). It is broken down by carboxylase enzyme (CES1) (Sun et al., 2004). From the point of pharmacokinetics, it may be suggested that CES1 gene polymorphisms may be the key responsible factors in patients resistan

• Fig A shows a schematic representation of histological resul

  2025-03-03

  

  Fig. 2A shows a schematic representation of histological results according to the Franklin and Paxinos Mouse Brain Atlas (2001). The black circles represent the sites of drug infusion that were on-target within the amygdala. Gray circles represent the animals that had infusion locations outside the

• br Results br Discussion Dopamine regulates

  2025-03-03

  

  Results Discussion Dopamine regulates behavioral responses to nicotine in Drosophila (Bainton et al., 2000), but neurochemical measurements of dopamine after nicotine stimulation had not been made. Here, we demonstrate for the first time that the stimulation of nAChRs causes dopamine release i

• br Autophagy in cancer br

  2025-03-03

  

  Autophagy in cancer Phytochemicals as a valuable source of autophagy modulation agents Epidemiological studies demonstrated that there is a strong association between diet and human cancer mortality so that daily consumption of phytochemicals declines the incidence of different types of cancer

• Arginases from several species and tissues have

  2025-03-01

  

  Arginases from several species and tissues have been found to be inhibited by amino acids [51]. In the present study, monocarboxyilic amino acids with five or more carbon atoms such as ornithine, lysine, valine, leucine and isoleucine inhibited CL-ARG. The results revealed that as the amino ACSF co

• Currently NSAIDs which achieve antineoplastic

  2025-03-01

  

  Currently, NSAIDs which achieve antineoplastic actions mainly through apoptosis are emerging choice in chemotherapy. Their antineoplastic effects were demonstrated before in tumor-bearing models [5], [6], [7]. Through in vitro cell models, we identified an indomethacin-activation of ceramide/PP2A/Ak

• br Consequences of central apelin

  2025-03-01

  

  Consequences of central apelin/APJ modulation Regarding extra-hypothalamic actions, recent data demonstrate that the central apelin/APJ system could be a potential new target for the regulation of memory (Han et al., 2014). Then, intracerebroventricular (icv) apelin administration in mice impairs

• The reduction of heterodimerization of

  2025-03-01

  

  The reduction of heterodimerization of KOR and APJ by both doses of apelin found in the present study may result in inducing protective effects of apelin on the myocardium imposed to high pressure in renovascular hypertension conditions. The finding that apelin in both doses reduced heterodimerizati

• The protein kinase CK mediated phosphorylation of HMGN

  2025-03-01

  

  The protein kinase CK2-mediated phosphorylation of HMGN1 was implicated to be involved in age-associated amnesia in rats [31]. It was shown that the decreased level of HMGN1 phosphorylation due to the down-regulation of CK2 activity could cause amnesia in aged rats, whereas the treatment with protei

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